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Piperine for Increased Bioavailability|organic chemistry of piperine|woman holding up thumbs up|woman holding a tape measure around waist


Did You Know That Piperine, Also Known as Black Pepper, Is a Nootropic?

There is a very good chance that you have never heard of the alkaloid piperine, but you probably know it under another name: black pepper . If you are interested in improving cognitive abilities, along with decreasing anxiety and stress, you might want to read further about the advantages of piperine.

History of Piperine

Piperine is extracted from black pepper and was originally discovered in 1819 by Hans Christian Ørsted. 1 This is the same Danish chemist who figured out that electric currents create magnetic fields.

Most people know that black pepper is a spice and seasoning often put on food, but this flowering vine that originally came from South India demonstrates serious nootropic benefits as well.

organic chemistry of piperine How Does It Work?

There is a certain science behind why piperine is so effective. Medical professionals say it is quite similar to the effects given off by grapefruit juice and St. John's wort . Piperine inhibits a drug metabolizing enzyme which allows it to stay in the body much longer. 2

This also increases the absorption rate by stopping the elimination of piperine in the liver and urine. The body and the brain are able to hold on to piperine even longer, resulting in increased effectiveness.

Benefits of Piperine

Piperine not only provides a boost to other nootropics you may be taking since it allows them to be present in your system longer, but it also shows a few nootropic capabilities on its own.

woman holding up thumbs up Battle the Blues

Piperine is a monoamine oxidase (MAO) inhibitor (MAOI) and inhibits both MAO-A and MAO-B. What does this mean? Well, a lot of research has shown that piperine is as effective for many as the over-the-counter antidepressant Prozac. 3

Piperine enhances the effects of serotonin in the brain by increasing its concentration in both the hippocampus and the frontal cortex.

Cognitive Enhancer

In one pre-clinical study, piperine was given to animals at various doses for a period of four weeks. The results demonstrated that piperine displayed the power to be a cognitive enhancer . Attention and focus were improved and overall brain function was improved. 4

Increased Absorption

Piperine may increase absorption depending on which chemical or drug it is taken with. For example, curcumin is a specific compound in turmeric, a quality nootropic supplement that is widely known to help the brain in several ways. In a 1998 study published in Planta Medica, supplementing with piperine increased the bioavailability of curcumin by 2000 percent without any adverse side effects. 5

Piperine metabolizes very slowly, which means it stays in the body longer and is, therefore, more effective. The same effects are extended to whichever supplement is taken with piperine.

woman holding a tape measure around waist Improved Metabolism

As people age, it is well known that metabolism starts to slow down. Remember how you could eat whatever you wanted in your twenties without gaining a pound? Fast forward to your thirties or forties, and this is no longer the case.

However, piperine is known to increase your metabolism as it breaks down fat cells and increases your internal temperature. 6 If you are having a tough time regulating your weight and keeping it under control, piperine could be a good addition to a solid weight loss program.

Safety and Precautions

When you take large doses of anything, there are certain consequences that can present themselves. You can overdose on vitamins if you go above and beyond the recommended dosage. If you take the recommended dosage of piperine, which is between 5 and 20 mg per day, then it should be perfectly safe. 7 These doses have also been shown to enhance bioavailability of nootropic supplements, so there is no need to take high doses.

Keep in mind that piperine will enable many of your medications to absorb better, so the therapeutic effects may be more prominent. Make sure you consult with a medical professional if you have any concerns about side effects or drug interactions.


Poor absorption rates for your supplements and medications is a valid concern, especially with how much money you spend on them. Piperine is known to improve the amount circulating in your body, so adding it to your daily routine should be a simple choice. Consider adding piperine to your nootropic stack to optimize the nootropic benefits.

Photo credits: molekuul_be/, Stokkete/, NarithThongphasuk/, kenary820/

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